Monoclonal Antibodies FAQs While vaccines provide the best protection from COVID-19, treatment options such as monoclonal antibodies are available if you have had symptoms of COVID-19 for 10 days or less or have been exposed to COVID-19. If taken early, they can reduce the risk of severe disease, hospitalization, and death. Ask your doctor about monoclonal antibodies or call the Combat COVID Monoclonal Antibodies Call Center at 1-877-332-6585 (English) or 1-877-366-0310 (Spanish). Download Flyer Find Treatment About Monoclonal Antibody Treatment What are monoclonal antibodies (mAbs)? Monoclonal antibodies, or mAbs, are lab-produced molecules that help your body fight off illness. Monoclonal antibodies can restore, boost or imitate your immune system’s response to the virus by replacing your natural antibodies. Antibodies are produced by your immune system to protect your body from things like viruses. Who is eligible for treatment? All high-risk adults and high-risk youth ages 12-17 who weigh at least 88 pounds may be eligible for treatment. High-risk factors can include: Older age Obesity or being overweight Pregnancy Chronic kidney disease Diabetes A weakened immune system or taking medicine that weakens your immune system Heart disease including high blood pressure Lung disease such as COPD, asthma, or cystic fibrosis Sickle cell disease Cerebral palsy or other developmental conditions Regular use of a feeding tube or ventilator Other non-medical factors such as race or ethnicity may also put individuals at higher risk for severe COVID-19. If you recently tested positive for COVID-19 and have had symptoms for 10 days or less, talk with your health care provider to see if monoclonal antibody treatment is right for you or search treatment locations to find a site near you. Additionally, people who are not fully vaccinated or who have a compromised immune system, including those taking immunosuppressive medications, and have either been exposed to COVID-19 or are at high risk of exposure due to where they live or work may qualify for preventative treatment. Treatment is not a substitute for vaccination against COVID-19. Who cannot receive this treatment? Monoclonal antibodies are not authorized for use in patients who: Are hospitalized due to COVID-19 Require oxygen therapy due to COVID-19 Require more oxygen that they normally would due to COVID-19 and those on chronic oxygen therapy due to an underlying non-COVID-19 related condition Are between the ages of 12-17 and weigh less than 88 pounds Are under age 12 If it has been more than 10 days since my symptoms started, can monoclonal antibodies still help? For the treatment to be effective, it should be given within 10 days of symptom onset. What mAb products are currently available? Bamlanivimab + Etesevimab: Manufactured by Eli Lilly and Company Authorized for emergency use on Feb. 9, 2021 Fact sheet for patients and caregivers: English / Spanish Casirivimab + Imdevimab: Manufactured by Regeneron Pharmaceuticals, Inc. Authorized for emergency use on Nov. 21, 2020 Fact sheet for patients and caregivers: English / Spanish Sotrovimab: Manufactured by GlaxoSmithKline LLC Authorized for emergency use on May 26, 2021 Fact sheet for patients and caregivers: English / Spanish How is mAb therapy different from the COVID-19 vaccines? A vaccine offers the best protection against a more severe case of COVID-19, including outcomes such as hospitalization or death, by triggering your body’s natural immune response if you are exposed to COVID-19. This is your best protection from COVID-19. If you have not been vaccinated, visit MySpot.nc.gov or call 888-675-4567. Monoclonal antibody treatment is for people who have tested positive for COVID-19 or have been exposed to the virus and who are eligible for treatment. The treatment gives your body the antibodies it needs to protect itself. What is the difference between mAbs and other COVID-19 treatments, including Veklury(R) (Remdesivir)? Monoclonal antibody treatment helps stimulate your immune system and prevents serious illness. Other treatments such as Veklury® (Remdesivir) are used to treat those that are already seriously ill with COVID-19. Veklury® (Remdesivir) is FDA approved for the treatment of COVID-19 in hospitalized patients 12 years of age and older who weigh at least 88 pounds. Monoclonal antibodies are for patients who are not hospitalized with COVID-19. Learn more about treatments for COVID-19. Getting the Treatment How can I receive this treatment? Monoclonal antibodies are administered by health care professionals through an intravenous (IV) infusion or through a shot (subcutaneous injection). The infusion takes anywhere from 20 to 60 minutes to complete, followed by 60 minutes of observation by your health care provider. There is no difference in effectiveness of treatment through an IV or shot. Find a clinic that offers this treatment near you or call the Combat COVID Monoclonal Antibodies Call Center for assistance: English: 1-877-332-6585 Spanish: 1-877-366-0310 How can I get a referral for this treatment if I do not have a health care provider? You do not need a referral from a doctor for mAb treatment at most locations, but you may need to make an appointment. When you call to make your appointment, a health care professional may ask some questions to determine whether you are eligible for treatment. Find a treatment location near you. Can I request this treatment at a pharmacy? Some pharmacies may offer monoclonal antibody treatment. Check with your pharmacy to see if they are a provider of monoclonal antibodies. What kind of COVID-19 test is required to qualify for this treatment? A laboratory report is not required for monoclonal antibody treatment but the date of your positive test and first date of symptoms are necessary to determine if you are eligible for the treatment. Can I receive this treatment if I do not have insurance? If you do not have health insurance, your provider may ask the federal government to pay for your treatment. This may require additional actions on your part, including filling out a form which would include your full name and date of birth, among other information. What if I don’t qualify for mAb treatment? Your health care provider may decide you don’t qualify for mAb treatment for any number of reasons, such as not meeting all the eligibility criteria, or having an underlying health condition that disqualifies you for mAb treatment. If you don’t qualify, there may be another option. You may be able to join a COVID-19 clinical trial. Clinical trial participants may receive new drugs or other treatments so researchers can evaluate how well the treatments work. Thousands of clinical trial participants have helped researchers discover new treatments for COVID-19, and many more participants are needed to ensure treatments work for people across age, gender, race and ethnicity. Ask your health care provider if you may be eligible for a clinical trial for treating COVID-19. To learn more about clinical trials, visit You Can Help Combat COVID or call 877-414-8106. Learn more about treatments for COVID-19. Treatment Side Effects and Safety Can I receive monoclonal antibody therapy if I am already fully vaccinated against COVID-19? Fully vaccinated people are less likely to develop severe symptoms of COVID-19, meaning they may not need monoclonal antibodies but this may vary based upon individual circumstances. If you are fully vaccinated and develop symptoms of COVID-19, you should contact your health care provider or call a COVID-19 monoclonal antibody provider location or Combat COVID Monoclonal Antibodies Call Center to determine if this treatment is right for you. What are the side effects of this treatment? Can I get COVID-19 from mAbs? Antibody treatments don’t contain any live SARS-CoV-2, so there’s no risk you’ll get COVID-19 from mAb treatment. However, antibody treatment may have side effects: Allergic reactions can happen during and after an antibody infusion. Tell your health care provider right away if you experience any signs or symptoms of an allergic reaction, including: fever; chills; nausea; headache; shortness of breath; low blood pressure; wheezing; swelling of your lips, face or throat; rash, including hives; itching; muscle aches; and/or dizziness. An infusion of any medicine may cause brief pain, bleeding, bruising of the skin, soreness, swelling and possible infection at the infusion site. Other side effects, including those that are serious and unexpected, are possible. Potential risks of antibody treatment include: Interference with your body's ability to fight off a future SARS-CoV-2 infection. Reduced immune response to a vaccine for SARS-CoV-2. Talk to your doctor or call the Combat COVID Monoclonal Antibodies Call Center (1-877-332-6585 for English or 1-877-366-0310 for Spanish) to determine if monoclonal antibody treatment is right for you. Is this treatment safe for pregnant women? This treatment can be given to women who are pregnant. Currently, there is no data that suggests this treatment should be avoided during pregnancy. Are mAbs safe for people receiving chemotherapy? Are there any known drug interactions? If you are receiving treatment for another condition, such as chemotherapy, you may still be a candidate for monoclonal antibody treatment to prevent serious illness. Your health care provider or treatment location will help determine if monoclonal antibody treatment is right for you. Can I receive this treatment more than once? How long do I need to wait between treatments? You can receive monoclonal antibodies more than once and it may be necessary that you receive a follow-up treatment. This will be determined by the treatment provider. After Your Treatment Can I get the COVID-19 vaccine after receiving mAb treatment? How soon after treatment? Yes, you can get vaccinated after monoclonal antibody treatment but should wait 90 days before getting a COVID-19 vaccine. Talk to your doctor if you are unsure what treatments you received or if you have more questions about getting a COVID-19 vaccine. Get additional information. Can I receive the COVID-19 vaccine if I experienced side effects from mAb treatment? If you experienced side effects from monoclonal antibody treatment, you should discuss these side effects with your health care provider or health care providers at the treatment location to determine the best course of action for you regarding vaccination and treatment. Can I get a flu shot after receiving mAb therapy? Yes. If you received monoclonal antibody therapy, you can still receive a flu shot but should talk with your provider about individual recommendations. Is it still possible to get COVID-19 even after receiving this treatment? Yes. Monoclonal antibody therapy is a treatment that can help people with COVID-19 recover faster and avoid hospitalization, but it is not a substitute for vaccination. COVID-19 vaccines offer the best protection from contracting COVID-19 in the future. Will mAb treatment impact my ability to donate blood or plasma in the future? Before donating blood or plasma, you should notify the facility that you have received monoclonal antibodies. You should not donate blood or plasma within 90 days of receiving monoclonal antibodies. The Science Behind the Treatment Were stem cells used to create this treatment? Human stem cells or human embryonic stem cells were not used in the development of mAbs. Were blood products use to create mAbs? Monoclonal antibodies are created in a lab and are not derived from human blood products. Additional questions? Call the Combat COVID Monoclonal Antibodies Call Center at 1-877-332-6585 (English) or 1-877-366-0310 (Spanish). For other COVID-19 questions call: 1-888-675-4567.